Beyond THC: The Entourage Effect Explained
The therapeutic benefits of the cannabis plant extend far beyond THC alone. Whole-plant medicine functions through the “entourage effect,” wherein minor cannabinoids and aromatic terpenes work synergistically with the human endocannabinoid system.
Dominant Therapeutic Terpenes
- Myrcene: Known for deeply relaxing, sedative, and anti-inflammatory properties. Common in indica-dominant chemovars.
- Caryophyllene: The only known terpene that directly binds to peripheral CB2 receptors, delivering potent anti-inflammatory and gastrointestinal benefits without psychoactivity.
- Limonene: Citrus-scented terpene associated with elevated mood, anti-anxiety benefits, and enhanced gastric absorption.
- Linalool: Floral, lavender-scented terpene providing calming, anticonvulsant, and sleep-inducing support.